Conditioned Place Pr

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 Conditioned Place Preference

The conditioned place preference paradigm is a standard behavioral model used to study the rewarding and aversive effects of drugs.


The basic characteristics of this task involve the association of a particular environment with drug treatment, followed by the association of a different environment with the absence of the drug. The apparatus consists of a three-compartment chamber designed to have different characteristics (e.g., white vs. black walls, different bedding, horizontal vs. vertical lines on the wall). The center compartment has no special characteristics and is not paired with a drug, and the gates between the compartments can be opened to allow an animal to pass freely between them. During training, a rat is given an injection of a drug with potentially rewarding or aversive properties, and is then placed into one of the outer compartments for several minutes. On the following day, the rat is injected with the drug’s vehicle and then placed in the opposite compartment. Generally, these daily sessions alternate between drug and vehicle for 2 or 3 days each. Afterward, a test session is conducted, which consists of placing the animal in the center compartment and then, after opening the gates to both of the outer compartments, recording the time the animal spends in each of the outer compartments during the session. A conditioned place preference (CPP) is found if the animals spend significantly more time in the drug-paired compartment versus the vehicle-paired compartment. On the other hand, if the animals spend significantly more time in the vehicle-paired compartment versus the drug-paired compartment, then this is considered a conditioned place aversion (CPA). 


Typically, drugs of abuse, such as cocaine, produce CPP, and drugs that elicit aversive effects, such as lithium chloride, produce CPA. 


Base dimensions (HxWxD)

30 cm X 30 cm X 40 cm


15 cm X 30 cm



Conditioned Place Preference